Following publication of a new systematic review and
meta-analysis in The Lancet
Obstetrics, Gynaecology, & Women's Health which
found no evidence that paracetamol use during pregnancy increases
the risk of autism spectrum disorder, ADHD or intellectual
disability among children, the MHRA has reaffirmed that
paracetamol continues to be the safest option for managing pain
and fever during pregnancy.
Dr Alison Cave, Chief Safety Officer at the MHRA,
said:
“Paracetamol remains safe to use during pregnancy. This
large-scale analysis of the evidence found no link between taking
paracetamol during pregnancy and autism, ADHD, or disability in
children.
“Paracetamol has been used for many years and is the recommended
first choice for treating pain or fever during pregnancy. When
taken as directed, it is safe and effective.
“As with all medicines, pregnant women should speak to their
doctor, pharmacist or midwife if they have any questions, and
follow the guidance provided with the medicine.”
Notes to Editors:
- Paracetamol is recommended as the first-choice painkiller for
pregnant women, used at the lowest dose and for the shortest
duration. If pain does not resolve, then patients are advised to
seek advice from their healthcare professional. See NHS Guidance
– Pregnancy, breastfeeding and
fertility while taking paracetamol for adults
- The MHRA regularly reviews the safety of paracetamol during
pregnancy to ensure that the benefits to the patient and unborn
baby outweigh any risks.
- Patients should not stop taking their pain medicines as
untreated pain and fever can pose risks to the unborn
child.
- Members of the public and healthcare professionals are
encouraged to report any suspected side effect from medicines,
including paracetamol, to the MHRA's Yellow
Card scheme.
