Latest findings from antibody surveillance study published
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Over 154,000 participants took part in a home surveillance study
for COVID-19 antibodies between 26 January and 8 February Findings
published by Imperial College London and Ipsos MORI show 13.9% of
the population in England had antibodies against COVID-19 17,000
participants had received at least one dose of a COVID-19 vaccine,
with 91% of people across all ages testing positive for antibodies
after two doses of the Pfizer vaccine Overall vaccine confidence
is...Request free trial
Imperial College London and Ipsos MORI have today published their latest antibody surveillance report tracking COVID-19 infection across England. For the first time, the study captures participants who have received a COVID-19 vaccine, and also gathers insight into how different groups feel about vaccines. Over 154,000 participants tested themselves at home using a finger prick test between 26 January and 8 February, showing 13.9% of the population had antibodies either from infection or vaccination. Of these participants, over 17,000 said they had received at least one COVID-19 vaccine dose. The data shows 87.9% of people over the age of 80 tested positive for antibodies after two doses of the Pfizer-BioNTech vaccine, rising to 95.5% for those under the age of 60 and 100% in those aged under 30. The findings show high confidence levels in the vaccine. Over 90% of those surveyed reported that they would be willing to accept, or had already had a vaccination for COVID-19. Today’s report provides insight on antibody responses following infection, or for some participants, vaccination. It does not provide insight on other elements of immune responses following vaccination – such as the presence of T-cells - nor does it assess vaccine effectiveness, including whether a vaccine prevents severe disease, hospitalisation or death. Health and Social Care Secretary Matt Hancock said: “These findings shed more light on rates of antibodies across the UK and among different groups, as we continue to strengthen our understanding of COVID-19. “It is fantastic to see over 90% of people surveyed would accept or had already accepted a vaccine, as we continue to expand the roll-out. “I urge anyone who has been invited for a vaccine to book an appointment. And while we are seeing rates of the virus gradually decline it is important we all hold our resolve and follow the rules as we deliver on our cautious but irreversible approach to easing lockdown.” Key findings:
The findings on antibody response following a single dose align with existing research that suggests those aged over 80 take longer to develop an antibody response to infection and the immune response is not as strong. Antibodies are just one component of the body’s immune response produced by COVID-19 infection or vaccination. Vaccines also induce T-cell related protection, independent of antibody production. T-cell responses may vary significantly between vaccines and may be particularly important in influencing duration of protection. The Joint Committee on Vaccination and Immunisation (JCVI) noted that in Pfizer’s clinical trial, protection against coronavirus was very high (89%) between 14 and 21 days after vaccination, despite very low levels of antibodies measured at the same time. This suggests that early antibody response does not correlate with clinical protection. There is still insufficient information to say how protected a person may be from COVID-19 based on a positive antibody test result, and it does not mean they are immune. It is vital everyone continues to follow the rules in order to keep themselves and those around them safe. Data from a Public Health Scotland study published this week has found that hospital admissions four weeks after the first dose were reduced by 85% and 94% for the Pfizer and AstraZeneca jabs respectively. Public Health England’s SIREN study also shows good evidence that the Pfizer-BioNTech vaccine helps to interrupt virus transmission, and that one dose is effective against the virus from three to four weeks after the first dose. PHE’s analysis of routine testing data also shows that one dose is 57% effective against symptomatic COVID-19 disease in those aged over 80. This effect occurs from about 3 to 4 weeks after the first dose. Early data suggests the second dose in over 80s improves protection against symptomatic disease by a further 30%, to more than 85%. Professor Helen Ward, lead author for the REACT study of population prevalence, said: “It is very encouraging to see that uptake and confidence in the vaccination programme is so high, and that most people develop a detectable antibody response after one dose. Our findings suggest that it is very important for people to take up the second dose when it is offered. We know that some groups have concerns about the vaccine, including some people at increased risk from COVID-19, so it is really important that they have opportunities to discuss these and find out more.” Kelly Beaver, Managing Director – Public Affairs, Ipsos MORI said: “It’s deeply encouraging to see such high levels of positivity towards receiving a COVID-19 vaccine among the population in our latest REACT study. That combined with our findings on the antibody response in those vaccinated show a cause for cautious optimism.” The study uses a finger prick device to use at home and can tell someone if they tested positive for antibodies in under 15 minutes. Some studies, including the PHE antibody surveillance studies, take a larger sample of blood to analyse in the lab. The REACT antibody data follows preliminary data from PHE on vaccine effectiveness showing clear protection from the first vaccine dose, particularly against severe disease. It supports the decision to maximise the number of people vaccinated with a single dose and delay a second dose. The government and the NHS are working hard to encourage people in all communities to come forward and accept the offer of a jab. This includes working closely with the NHS and faith and community groups, to support and reach people who are eligible for a vaccine, by providing advice and information in over thirteen languages. Over £23 million funding has already been allocated through the Community Champions scheme to 60 councils and voluntary groups across England to expand work to support those most at risk from COVID-19 and boost vaccine take up. Notes to editors The embargoed report can be downloaded here: Password: REACT2_R5 Link: https://imperialcollegelondon.box.com/s/k61fhjwekx9eefeq3vr074j23l34o93i Key findings between 26 January and 8 February: Overall prevalence of antibodies:
Vaccination:
Vaccine confidence:
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